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ICRP International

Conference on Recovery After Nuclear Accidents

Radiological Protection Lessons
from Fukushima and Beyond

December 1 - 18, 2020

Y. Gondo

Updated: Dec 10, 2020

Attempt to Detect Long-term Exposure-induced Mutations in Trace Radiation Based on Whole-genome Decoding

Y. Gondo (Tokai University School of Medicine, Japan)


Natural mutation detection and analysis for single base substitution (SNV) using whole genome sequencing (WGS) based on the ultrafast sequencing method is advancing. The mutation rate in humans is reported to be 1.2 × 10-8/bp/generation. In the case of a human having 3 × 109 bp diploid genomes, it works out to an average of 72 mutations, not found in either parent, naturally developing in any children. As for mice, the genomes after accumulation of mutations through sib mating have been decoded and analyzed, and the rate of natural